Mechanisms of Action Quiz 3

Welcome to your Mechanisms of Action Quiz 3

1. Which of the following drugs works by inhibiting the enzyme catechol-O-methyltransferase?

Entacapone

Rasagiline

Orphenadrine

Tetrabenazine

2. Which of the following drugs works by inhibiting the enzyme dihydroorotate dehydrogenase?

Chloroquine

Mesalazine

Leflunomide

Etanercept

3. Which of the following statements about febuxostat is true?

Inhibits reabsorption of uric acid in the proximal tubule

Reduces production of TNFα by macrophages

Catalyses oxidation of uric acid to soluble allantoin

Inhibits xanthine oxidase to reduce uric acid formation

4. Which drug has keratolytic action – an effect which unblocks the pilosebaceous follicles and reduces sebum production by up to 90 percent?

Isotretinoin

Clindamycin

Benzoyl peroxide

Azelaic acid

5. What is the mechanism of action of the HIV drug raltegravir?

Binding-fusion-entry inhibitor

CCR5 Co-receptor antagonist

Integrase inhibitor

Viral DNA polymerase inhibitor

6. Anakinra – a drug used in the treatment of rheumatoid arthritis – works by which means?

T-cell co-stimulation modulator

Interleukin-1 receptor antagonist

Anti-CD20 B-cell depleter

As an antibody against TNFα

7. Which of the following drugs works by irreversibly inhibiting the H+/K+-ATPase pump in order to reduce acid secretion?

Aluminium hydroxide

Cimetidine

Omeprazole

Metoclopramide

8. Mifepristone is a potent progesterone antagonist used to induce abortion.

True

False

9. Triptans – drugs which are used in the treatment of migraine – work by primarily agonising which receptors?

5HT1B/1D

5HT1C/1D

5HT1E

5HT1B/1C

10. Fludrocortisone is one of the principal glucocorticoids with notable immunosuppressant, anti-inflammatory, metabolic, and CNS effects.

True

False