Each week we compile all the latest pharmacology facts released on our social media platforms. This is great pharmacology for students, as these facts are bite-sized, random, and often important facts that all students of medicine should commit to memory.
- Pralidoxime is used as an antidote to organophosphate poisoning; flumazenil is used for benzodiazepine poisoning, whereas Prussian blue is used for thallium poisoning.
- Canrenone is the active metabolite of the diuretic drug, spironolactone.
- Carbonic anhydrase inhibitors (eg. acetazolamide) are a class of diuretics that act at the proximal tubule.
- Uses of mannitol (Osmitrol) include increased intracranial pressure and as an osmotic laxative.
- Osmotic diuretics (Mannitol) work by inhibiting reabsorption of water and sodium; increasing osmolarity of blood + renal filtrate.
- Colchicine - Originally extracted from crocus, Colchicum autumnale. Its uses include gout, familial Mediterranean fever and Behcet’s disease.
- Colchicine inhibits microtubule polymerization by binding to tubulin; tubulin being essential to mitosis; it also inhibits neutrophil activity.
- What is Behçet's disease? It is immune-mediated small vessel systemic vasculitis. Symptoms include recurrent ulcers, uveitis and pericarditis.
- Verapamil (Class IV antiarrhythmic) is a calcium channel blocker used to treat hypertension, angina, heart rhythm disorders. Side effects include constipation, dizziness, nausea and hypotension.
- Leuprolide is a gonadotropin-releasing hormone (GnRH) analogue. Its uses include prostate cancer symptoms, endometriosis and uterine fibroids.
- Leuprolide (implant/inj.) is an agonist at pituitary GnRH receptors; downregulating secretion of LH, FSH - leading to hypogonadism.
Mnemonics and mindmaps are also another great way to commit pharmacology to memory. But if you’d like to learn more about specific drug classes, check out these more detailed articles for more information.
Take two minutes to check out last week's facts here!