Pharmacology Facts (21-26 August)

Each week we compile all the latest pharmacology facts released on our social media platforms. This is great pharmacology for students, as these facts are bite-sized, random, and often important facts that all students of medicine should commit to memory.

If you haven’t already, be sure to check out our Facebook and Twitter feeds for all the latest articles, infographics, and facts. These facts were released during the period 21-26 August.

  • Food decreases levels of erythromycin in the body, it's therefore advised to be taken 1 hour before or 2 hours after meals.
  • Tuberculosis treatmentPRIEST: Pyrazinamide, Rifampin, Isoniazid, Ethambutol, Streptomycin.
  • Leprosy treatmentDemocratic Republic of the Congo: Dapsone, Rifampicin, Clofazimine.
  • Antidepressants VII: Non-selective, irreversible MAOIs - Tranylcypromine - Phenelzine – Isocarboxazid (TIP).
  • Antidepressants VI: Serotonin Modulators and Stimulators (SMSs) - Vilazodone – Vortioxetine.
  • Antidepressants V: Serotonin Antagonist and Reuptake Inhibitor (SARI) - Trazodone NRI – Reboxetine.
  • Antidepressants IV: Tetracyclic Antidepressants (TeCAs) - Amoxapine - Mianserin - Mirtazapine – Maprotiline.
  • Antidepressants III: TCAs - Amitriptyline - Clomipramine - Desipramine - Doxepin - Dosulepin - Imipramine – Nortriptyline.
  • Antidepressants II: SNRIs - Desvenlafaxine - Venlafaxine - Duloxetine - Levomilnacipran – Milnacipran.
  • Antidepressants I: SSRIs - Citalopram - Escitalopram - Paroxetine - Fluoxetine - Fluvoxamine – Sertraline.
  • Cephalosporins II: 4th Gen - Cefepime (covers pseudomonal infections), 5th Gen (MRSA) - Ceftaroline – Ceftobiprole.
  • Cephalosporins: 1st Gen - Cefadroxil - Cefazolin – Cefalexin, 2nd Gen - Cefaclor – Cefuroxime, 3rd Gen - Cefixime - Cefotaxime – Ceftriaxone.
  • Tetracyclines (eg. Minocycline) - Binds to 30S ribosomal subunit, Lipopeptides (eg. Daptomycin) - Disrupts membrane potential.
  • Quinolones (eg. Ciprofloxacin) - Inhibits DNA replication gyrase/topo-IV Sulfonamides (eg. Sulfamethoxazole) - Inhibits folate synthesis.
  • Oxazolidinones (eg. Linezolid) - Blocks initiation step, protein synthesis, Penicillins (eg. amoxicillin) - Disrupts peptidoglycan synthesis.
  • Monobactams (eg. Aztreonam) - Disrupt peptidoglycan synthesis, Nitrofurans (eg. nitrofurantoin) - Damages bacterial DNA.
  • Lincosamides (eg. Clindamycin) - Inhibits protein synthesis (50S), Macrolides (eg. Clarithromycin) - Inhibits protein synthesis (50S).
  • Cephalosporins (eg. Cefuroxime) - Disrupt peptidoglycan synthesis, Glycopeptides (eg. Vancomycin) - Inhibits peptidoglycan synthesis.
  • Aminoglycosides (eg. Gentamicin) - Protein synthesis inhibitors (30S/50S), Carbapenems (eg. Imipenem) - Cell wall synthesis inhibitor.
  • Examples of beta-lactamase inhibitors - Clavulanic acid (w/ amoxicillin/ticarcillin) - Tazobactam (w/ piperacillin).
  • Calcium channel blockers " -dipine ", Dihydropyridine: Amlodipine - Nifedipine – Nimodipine, Non-Dihydropyridine: Diltiazem – Verapamil.
  • Tetracyclines are associated with an increased risk of teeth staining and skin photosensitivity. They are inactivated by Ca, Al, Fe, and Zn.
  • Aminoglycosides - such as gentamicin - are associated with an increased risk of ototoxic and nephrotoxic side effects.
  • Quinolones - such as ciprofloxacin - are associated with an increased risk of tendonitis and tendon rupture.

Mnemonics and mindmaps are also another great way to commit pharmacology to memory. But if you’d like to learn more about specific drug classes, check out these more detailed articles for more information.

Check out last week's pharmacology facts here!

By | 2016-12-11T18:16:28+00:00 August 26th, 2016|Weekly Facts|0 Comments

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