What is iron?
Most people receive enough iron through their diet; an essential mineral for red blood cells. In fact, almost three-quarters of the body’s iron can be found inside red blood cells; their role involving, in part, the transport of oxygen and carbon dioxide around the body.
Food sources high in iron include red meat, poultry, lentils, beans, green-leafy vegetables and liver. The bioavailability of iron from plant sources is substantially lower than from meat sources, meaning vegetarians/vegans need to consume more iron than meat-eaters.
Many people are diagnosed with iron deficiency for a wide range of reasons. Causes include chronic bleeding, an inadequate dietary intake of iron, taking drugs that interfere with iron absorption, and malabsorption syndromes, amongst others.
Iron levels need to be replenished, but with this replenishment – whether from supplements or dietary sources – comes the risk of iron interactions with other foods or drugs. Here, we sketch out some of the most prominent examples of these interactions.
Common iron interactions
There are three main, different ways in which iron interactions can manifest:
- Drugs that reduce the absorption of iron
- Iron that decreases the absorption of other drugs
- Drugs that increase iron levels
We’ll go through each of these manifestations in turn.
First, drugs that reduce the iron absorption. These drugs are few, but their effects still hold clinical significance. Colestipol and cholestyramine (lipid-lowering agents of the bile acid sequestrant class) are, for example, known to reduce iron absorption.
Drugs that affect stomach acid production, such as H2 antagonists and proton pump inhibitors, also impair iron absorption. H2 antagonists include famotidine and ranitidine, whereas proton pump inhibitors include omeprazole and pantoprazole.
Second, iron as a substance that reduces absorption of other drugs. Iron reduces the absorption of quinolones, ACE inhibitors, bisphosphonates and tetracyclines. Iron may also reduce the effectiveness of levothyroxine and carbidopa/levodopa.
Third and finally, drugs that can increase iron levels. Members of this distinguished class include birth control medicines. It’s worth noting that some iron interactions are more pronounced than others, whereas some interactions have somewhat limited effects.
Overcoming iron interactions
Patients are often recommended, when faced with the above interactions, not to consume iron supplements within 2 hours of taking that medicine – both before and after. This eliminates the contact risk between supplement and drug and/or drug effects.
Think about tetracyclines. The effect of tetracycline antibiotics is reduced if taken with iron supplements. Iron works to chelate the tetracycline structure, inactivating its therapeutic potential. Iron needs to be avoided while the antibiotic is being absorbed.
The above list is by no means intended to be exhaustive. If you can think of other drug interactions with iron, drop that interaction in the comments section below.