Half-Life & The Elimination Constant

December 28th, 2016

Now that we have covered what is meant by terms volume of distribution and clearance, we can now turn out attention to yet another key pharmacokinetic parameter – the elimination constant, kel. The elimination constant is closely linked to the ‘half-life’ of a drug in the body, therefore this article attempts to explain what both […]

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Basic Principles of Drug Clearance

July 27th, 2016

Now that the basic concepts of volume of distribution and the elimination rate constant have been introduced, we can start talking about one of the more challenging but certainly one of the most important concepts of pharmacokinetics – drug clearance. Secondly, it’s worth prefacing that this article assumes that readers have a basic knowledge of […]

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Basic Pharmacokinetic Concepts – Apparent Volume of Distribution

March 14th, 2016

Have you ever wondered about what happens when you swallow a tablet of ibuprofen? How does it get from your gut to the circulation? What happens to it in your blood and tissues? How does it know where to go to ‘kill’ your pain? More importantly, in case you took it to combat the pain, […]

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Basic Pharmacodynamics: Drug-Receptor Interactions Explained

January 27th, 2016

How do we study and quantify the effect a drug has on the body? In order for a drug to exert its effects, it needs to reach its site of action. The study of how it gets to its target site and, subsequently, how it gets eliminated from the body, is the subject of pharmacokinetics. […]

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